One person was injured in the crash, which happened around 4:30 a.m. on Wednesday.
A crash on Interstate 65 in IN led to the leak of hazardous chemicals, and police have said that first responders are facing an explosion risk.
One of the trucks was carrying hazardous material.
Eventually, the truck caught fire, posing what police called an "explosion risk" and prompting officials to issue a non-mandatory evacuation of the surrounding areas.
Eastbound lanes remained closed almost the entire day, only reopening sometime after 8 p.m.
Sgt. Stephen Wheeles noted that the fire situation on I-65 is continuing to deteriorate, saying that portions of the highway have been closed down. Southbound lanes remained closed until 9pm.
According to WLKY, both the north and southbound lanes are shut down on I-65 following a crash involving three tractor trailers.
Police are still investigating the crash.
The entire interstate was shut down in both directions just before 8:30 a.m., with lanes not reopening until after 1 p.m.
As a result of the crash, some of the chemicals from Okpeh's vehicle spilled inside the trailer and onto the roadway.
Stephen Wheeles first said the southbound lanes would be closed until about 2 p.m. ISP later closed all lanes and evacuated houses within half a mile.
The investigation is ongoing.