With Tottenham having only won one of their last five games in all competitions, Pochettino said Luke Amos and Kazaiah Sterling will be among those involved against the Cypriot side, who can not qualify but are battling with Borussia Dortmund for third place.
Michael Owen is backing Tottenham to secure a comfortable victory over Apoel Nicosia in their final Champions League group game on Wednesday night.
But Pochettino, who has no issues with the way his side are now performing, insists Wednesday's match is an opportunity to regain their form ahead of games against Stoke, Brighton and Man City. "We are frustrated because the results are not good but it's not about the performances".
"We have maybe three points less than this time last season, and we've finished top of our Champions League group". "We want to avoid bad periods but we are not still this type of team like Barcelona, Real Madrid that can maybe keep winning for long periods".
Harry Kane will be among five key men rested for the match at Wembley along with Christian Eriksen, Eric Dier, Kieran Trippier and Hugo Lloris. "He needs to play", Pochettino told a news conference on Tuesday.
"Manchester City have created a gap, but I'm sure the team will improve and take many lessons from this run". "He's doing well, we need to assess him day by day, week by week", he said. Then it's a great opportunity to show to the gaffer and the fans that they are available to play and can be regularly in the starting XI.
Midfielder Victor Wanyama will miss the meeting with the Cypriot champions with a knee injury while Erik Lamela, just back from a hip problem, is ineligible as he was not included in the club's initial Champions League squad.