The Bills managed 198 yards, and 10 first downs.
The New Orleans Saints embarrassed the Bills by running 24 consecutive times in the second half of a 47-10 romp at New Era Field, including rushes on all 10 plays of a 94-yard touchdown drive in the third quarter.
Here are the top takeaways from the Bills' gut-wrenching loss.
"At all?" Brown said with a heavy sigh. "They killed us in every single stat, everything you could talk about. We've got to get better". We're 5-4. Nobody said, like I told you before, nobody said this is easy. "5-4 is not bad as a record".
The Saints set a franchise record, having scored six rushing touchdowns in a game.
The touchdown run capped a big series for Ingram.
Tight end Charles Clay returned to the Bills lineup on Sunday and his inability to reel in a pass from Tyrod Taylor helped the Bills take their lead up to 27 points in the third quarter. Ingram and Kamara each surpassed 100 rushing yards and 130 yards from scrimmage.
The Bills punted on their following possession, but at least looked to be in good shape when a penalty backed the Saints up to their own 6-yard. Drew Brees scampered in from 7 yards.
"We're actually committing to it, as a coaching staff, everybody's buying into it as players", Ingram said of what's so different with New Orleans' run game this year.
"It just snowballed into a nightmare", defensive tackle Kyle Williams said.
"When you're giving up rushing yards like that, it goes beyond the physical aspect of it". "We're in wrong places, we're not where we're supposed to be".
New Orleans' run game and defense have been the driving forces behind the team's longest win streak since 2011. "OK, second and 20" ... first down. He was not alone in the struggle, as the rest of the Bills offense failed to get anything going on Sunday.
Traditionally one of the most prolific passers in the game, Brees has passed for more than 300 yards twice this season. Bills rookie corner Tre'Davious White, a former LSU standout, was a nonfactor.
Sunday's game marks the first time since 1986 that the Saints rushed for more than 250 yards in a single game.
"We came out, and we wanted to impose our will", Kamara said.
"We got whooped physically", he said.