The twosome will ring in 2018 from Times Square in NY on CNN's "New Year's Eve Live with Anderson Cooper and Andy Cohen" on Sunday, December 31.
Said Cohen, "I've been friends with Anderson for twenty-five years. We've traveled the world together and performed in 30 plus cities with 'AC2, ' and it's all led to this one huge night!"
The opportunity for Cohen opened after CNN fired Griffin over the summer when she posted a controversial photo showing an effigy of President Donald Trump's severed head. It is clearly disgusting and completely inappropriate", he wrote at the time. The two tour regularly and host a night of conversation across the country.
Cohen is the host of Bravo's "Watch What Happens Live", so he knows the hosting routine.
Cohen also has a long-standing relationship with Griffin from his time as a network executive at Bravo.
CNN is bidding auld lang syne to the team that has helped its viewers ring in the New Year since 2007.
Due to their long-standing friendship, Cohen and Cooper have frequently appeared on each other's program.
Cohen "could not be more excited", he said in a Tweet.