The IRGC claimed that the strike was in retaliation for the terrorist attack which killed 17 civilians in Tehran earlier this month, but many have speculated that the Regime planned the terror attack themselves in order to gain sympathy from the global community as the victims were mainly people protesting the Iranian Regime.
Just days after the missile strike, Iranian drones targeted US forces in Syria for a second time, demonstrating that Tehran is committed to a new policy of direct action against USA -backed forces.
The strike was "revenge" for twin attacks in Tehran on June 7 that killed 17 people in the first IS-claimed attacks inside the Shiite-ruled Islamic republic, a Guards spokesman added.
President Bashar al-Assad's forces, aided by Iranian-backed militias, have engaged in a race with FSA rebels in recent weeks to seize areas in the southeastern desert vacated by retreating Islamic State insurgents.
But the missiles sent a message to more than just the extremists in Iraq and Syria, Sharif told state television in a telephone interview.
Syrian opposition activist Omar Abu Laila, who is based in Germany but closely follows events in his native Deir el-Zour, said two Iranian missiles fell near and inside Mayadin, an Islamic State stronghold.
He billed Iran's retaliatory missile strike as a countermeasure of just a "very limited scale".
Israel and Iran are bitter enemies.
The larger problem, the officials and analysts said, is that Trump and his national security team have not advanced a long-term political strategy for Syria's future.
Frants Klintsevich, deputy head of the defense committee in Russia's upper house of parliament, said the defense ministry statement does not mean there will be war with the U.S.in Syria, but rather that Moscow will not accept attacks on its Syrian allies.
The Zolfaghar missile, unveiled in September 2016, was described at the time as carrying a cluster warhead and being able to strike as far as 700 kilometers (435 miles) away. "The coalition does not seek to fight the Syrian regime, Russian, or pro-regime forces partnered with them, but will not hesitate to defend coalition or partner forces from any threat".
But he warned that Iraq "should not trust" the United States, which is leading a coalition fighting IS in Iraq and neighbouring Syria.
Iranian media reported that it was the first time the country's armed forces had used such missiles outside its country in thirty years.
"We have never had a coherent Syrian strategy", said one USA official, speaking on condition of anonymity.